Synthetic adrenal steroid fludrocortisone, which possesses potent mineralocorticoid activity. Normally prescribed for adrenocortical insufficiency, its versatile off-label applications extend to managing orthostatic hypotension and postural orthostatic tachycardia syndrome.
Fludrocortisone acetate is an inactive pro-drug requiring hydrolyzation by esterases or pseudo-esterases in the liver and other body fluids. Fludrocortisone is a synthetic adrenal steroid with high mineralocorticoid activity and is practically devoid of glucocorticoid effect.