Chronic, multisystem autoimmune disorder characterized by lacrimal and salivary gland inflammation, with resultant dryness of the eyes and mouth and occasional glandular enlargement.
IgG4
Clinical
Persistent symptoms of dry eyes and/or mouth
Parotid gland enlargement
An unexplained increase in dental caries,
Diagnosis
Objective marker of dry eye or salivary hypofunction/characteristic MRI or ultrasound
Characteristic autoantibodies or labial salivary gland biopsy or systemic autoimmune disease
Anti-Ro/SSA and/or anti-La/SSB antibodies, rheumatoid factor, and hyperglobulinemia