Leukaemia

Acute Leukaemia

• Neoplastic disease of immature cells (blasts) in the bone marrow
• Two lineages
  • Myeloid lineage
    • Acute myeloid leukaemia (common myeloid progenitor cells)
  • Lymphoid lineage
    • Acute lymphoid leukaemia (common lymphoid progenitor cells)

Chronic Leukaemia

• Neoplastic disease of mature cells in the bone marrow
• Two lineages
  • Myeloid lineage
    • Chronic myeloid leukaemia
  • Lymphoid lineage
    • Chronic lymphoid leukaemia

Myeloproliferative disease

• Group of neoplastic disorfers involving the bone marrow cells that produce RBC, platelets or fibroblasts
  • Polycythaemia Rubra Vera - RBC
  • Essential thrombocythaemia - Platelets
  • Myelofibrosis - Fibroblast

Myelodysplastic syndrome

• Pre-cancerous disease of bone marrow, where the dysplastic cells may cause abnormal and inadequate cell production, and may also progress to leukaemia.