UDCA markedly decreases biliary cholesterol saturation by inhibiting the absorption of cholesterol in the intestine and its secretion into bile, demonstrated by reduced cholesterol fraction of biliary lipids.
Reduces cholesterol absorption hence in theory reduced bile acid production
Indications
- UDCA is commonly used to treat patients with Primary Biliary Cholangitis
- treatment in intrahepatic cholestasis
- Gallstones/sludge
- Bile Reflux Gastropathy