- Direct continuation of the Brachial Artery in the Cubital fossa
- Passes distally medial to Biceps Tendon
- Passes across Supinator
- Lies medially beside the Radial Nerve in the middle third
- Passes over tendon of insertion of Pronator Teres, radial head of Flexor Digitorum Superficialis, origin of the Flexor Pollicis Longus, insertion of Pronator Quadratus, and lower end of the Radius
- In upper forearm, overlapped anteriorly by Brachioradialis
- Disappears deep to the tendons of Abductor Pollicis Longus and Extensor Pollicis Brevis to across the Anatomical Snuff Box