Classification

  • Based on thier hemolytic properities
    • Alpha
      • Causes oxidation of iron within red blood cells
    • Beta
      • Causes lysis of red blood cells
      • Further classified into Lancefield grouping
    • Gamma
      • No heamolysis

Alpha

  • In alpha hemolysis, the red blood cells remain intact, but the hemoglobin is converted to biliverdin. This causes dark greening of the blood agar plate around the colonies.
  • Pneumococci
    S. pneumoniae: Causes bacterial pneumonia, otitis media and meningitis. 

Beta

  • Beta hemolysis is a complete hemolysis of erythrocytes by the enzyme hemolysin.

  • Clear zones will appear around the colonies on the blood agar plate.

  • Beta-hemolytic Streptococci are further divided into serological groups using specific antibodies that recognize surface carbohydrate antigens

  • Group A Streptococcus S. pyogenes: Causes infections like strep throat, acute rheumatic fever, scarlet fever, acute glomerulonephritis and necrotizing fasciitis. Other Streptococci species may also possess the Group A antigen but are not human pathogens. These include S. dysgalactiae subsp. equisimilis and S. anginosus strains.

  • Group B Streptococcus S. agalactiae: Causes meningitis in neonates and the elderly. Occasionally colonizing the female reproductive tract, they increase the risk for premature rupture of membranes and transmission of the infection to the child.

  • Group C Streptococcus S. equi: Causes strangles infection in horses.
    S. zooepidemicus: Causes infections in cattle, horses and other mammals.

  • Group D Streptococcus (Enterococci)
    Many former Group D Streptococci have been reclassified to the genus Enterococcus (e.g. S. faecalis, S. faciem, S. durans, S avium).
    S. bovis and S. suis: Still in the Group D streptococci.

Gamma

  • Gamma hemolysis is a misnomer as there is actually no hemolysis. Non-hemolytic or gamma-hemolytic Streptococci rarely cause disease.