CHEK2

• 22q12, Checkpoint kinase 2 gene, Tumour Suppressor
• AR
• Considered a “moderate risk” cancer gene
• Cancer risk
  • Breast
    • Risk depends on mutation but in general RR 2 of breast ca, x 10 in males
  • Colorectal
    • Maybe increase risk
• Screening
  • Breast MRI starting age 30
    • Minimal evidence