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Antimetabolites of purines
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Used as maintenance therapy in IBD. Not for induction
Must check Thiopurine methyltransferase enzyme (TPMT) activity
- Low TPMT activity have been associated with an increased risk of myelotoxicity, especially in Caucasians
- High TPMT activity are called “hypermethylators” or “non-responders” because they mainly produce methylated inactivated products of AZA