Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR) Jing Jin, MD1,2 ; Yuan Tang, MD 1 ; Chen Hu, PhD3 ; Li-Ming Jiang, MD 4 ; Jun Jiang, MD4 ; Ning Li, MD1
STELLAR orginal, page 1
Publication information
Journal of Clinical Oncology, 2022
Hypothesis:
To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.
Methods
Design
Inclusion
Distal or middle-third, clinical primary tumor stage 3-4 and/or regional lymph node–positive rectal cancer.
Procedure
Exp: SCT + chemo vs CRT Both received adjuvant chemotherapy (2 cycles in Exp vs 6 in standard of care)
Outcome
3y DFS
Results
Population
599
Primary endpoint
DFS - 64.2 vs 62.5% MFS - 77.1 vs 75.3% LRR - 8.4% vs 11% OS 86.5 vs 75.1%