Familial hуреrаlԁοѕterοոism (FH) is an uncommon subset of primary аlԁοѕtеrоոiѕm. Four forms of FH exist:
- FH type I or glucocorticoid-remediable аlԁοѕterоnism (GRΑ) due to a CYP11B1/CYP11B2 chimeric gene
- Treat with glucocorticoid therapy
- FH type II caused by germline CLCN2 pathogenic variants
- Treatment of FH type II are the same as for sporadic primary аlԁοѕterοnism
- FH type III caused by germline KCNJ5 pathogenic variants
- FH type IV caused by germline CACNA1H pathogenic variants