Atezolizumab

• Immune checkpoint inhibitors which is a type of Immunotherapy

• Atezolizumab is a humanized IgG1 monoclonal anti-programmed death-ligand 1 (PD-L1) antibody

• Programmed cell death protein ligand1 (PD-L1) inhibitor

• PD-1

  • Transmembrane protein expressed on T cells, B cells, and natural killer (NK) cells
  • It is an inhibitory molecule that binds to the programmed cell death ligand 1 (PD-L1)
  • The PD-1:PD-L1/2 interaction directly inhibits apoptosis of the tumor cell, promotes peripheral T effector cell exhaustion, and promotes conversion of T effector cells to Treg cells