Pancreatic Polypeptide
- 36–amino acid polypeptide secreted by F cells (1-2%, lie peripherally)
- From islets in HOP from ventral bud
- Belongs to YY/neuropeptide Y family.
- Causes loss of appetite and reduced food intake
- Inhibits exocrine pancreas & biliary emptying
- Physiologic role is unclear
- Clinical usefulness is limited to role as a marker for other endocrine tumours of the pancreas
- Secretion regulated by cholinergic innervation
- Surgical vagotomy ablates the increased PP response normally observed after meals
- In diabetes and normal aging, PP secretion is increased
- Absence of PP may play a role in diabetes observed after total pancreatectomy or after chronic atrophic pancreatitis