Recipient Liver resection

  • Transverse abdominal incision with a midline extension
    • Diseased liver is mobilised
    • Because of portal hypertension, the recipient hepatectomy is often the most difficult part, esp. if previous surgery
    • CBD divided as close to liver as possible
    • Mobilisation
      • Dissect the intrahepatic vena and control it with a nylon tape.
      • Divide the peritoneal attachments of the liver, starting with the left triangular ligament and proceeding to the falciform ligament, thus exposing the anterior surface of the supra-hepatic vena cava.
      • Completely mobilising the retrohepatic vena cava from the posterior abdominal wall, ligating and dividing the right adrenal vein.
    • Ligate the portal vein and hepatic artery - maximising the length of the vessels for subsequent re-implantation of the new graft.
  • Occlusion of the vena cava and portal vein results in a reduction in cardiac output and may necessitate the use of veno-venous bypass

Liver implantation

  • After placing the donor liver in position
    • Supra- and infrahepatic caval anastomoses are performed
    • The portal vein and the hepatic arterial anastomoses are then completed and the graft is reperfused
    • Finally, biliary drainage is re-established
      • Duct-to-duct anastomosis, end-to-end (without a T-tube)
      • Roux-en-Y may be needed for biliary atresia or sclerosing cholangitis
  • Many pts undergoing liver transplantation are ill and the surgery involved can be very demanding
  • Optimal peri-operative management crucial for success and presents a major challenge
    • Blood loss during and after the transplant procedure can be considerable
    • Management of coagulopathy is particularly important
    • Measured repeatedly and corrected appropriately with FFP, cryoprecipitate and platelets