- Clonal selection model
- Clonal expansion, growth, diversification, angiogenesis
- Subclone randomly acquires the necessary traits to disseminate successfully
- Adhesion to and invasion of basement membrane
- Passage through ECM
- Intravasation
- Tumor cell embolus
- Adhesion to basement membrane
- Extravasation
- Metastatic deposit
- Angiogenesis and growth
