- Characterised by presence of Antiphospholipid Antibody
- Against plasma proteins bound to anionic phospholipids
- Lupus Anticoagulant
- Anticardiolipin
- Antibodies to B2 Glycoprotein-1
- Clinical
- Arterial & venous thrombosis, recurrent fetal loss, thrombocytopenia
- Venous is more common
- Arterial manufactures as stroke
- Second hit – smoking, prolonged immobilisation, pregnancy, malignancy
- Can be associated with SLE
- Management
- Same treatment as other thrombotic disease but lifelong warfarin
- Asymptomatic carriers don’t get started on regular warfarin
- Long-term aspirin if associated with SLE