- Generation of oxygen free radicals → Attach to FAs in phospholipids membrane ⇒ Mechanical & functional derangements
- Release of ischaemic metabolites from muscle ischaemia leads to SIRS
- Proteins (myoglobin), enzymes & K+ that are released from damaged cells are washed out to the circulation
- ↑ Myoglobin → Acute renal impairment
- ↑ K+ ⇒ Possible Arrhythmias