PALB2

• Autosomal Dominant
  • PALB2 (Partner and Localizer of BRCA2) encodes a BRAC2-interacting protein
    • Tumour Suppressor
• Lifetime Breast Ca Risk: 44%
• Associated with ER -ve Ca (i.e. less likely to work with Tamoxifen risk-reduction strategy)
• Also Ovarian and Pancreatic Ca
• Biallelic mutation (Autosomal Recessive) in PALB2 gene causes Fanconi Anaemia
• Screen with MRI starting age 30