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TOPGEAR trial

TOPGEAR trial

  • RCT gastric + GOJ - ChemoRTx vs Chemo - Chemo was ECF or FLOT4
  • No difference in overall survival or progression free survival
  • No benefit from the addition of radiotherapy to neoadjuvant chemotherapy

NEJM 2024 - https://www.nejm.org/doi/full/10.1056/NEJMoa2405195


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  • Gastric adenocarcinoma
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