Painful white swollen leg, thrombosis of Iliac/ Femoral Veins

Clinical examples of Phlegmasia Alba dolens (A) and Phlegmasia Cerulea dolens (B and C).

Phlegmasia alba and cerulea dolens are rare manifestations of  acute deep venous thromboses. Phlegmasia alba dolens (upper image), which translates to “painful white inflammation,” occurs when venous thrombosis progresses to a massive occlusion of the major deep venous system of the leg, but without ischaemia as collateral veins are still patent. The pallor is due to arterial spasm. Phlegmasia cerulea dolens translates to “painful blue inflammation” and is the next progression of the disease, characterised by complete thrombosis of the deep venous system, including the collateral circulation. This results in significant venous congestion, fluid sequestration, and worsening oedema.