- Post-thrombotic syndrome
- Syndrome consists of symptoms and signs of chronic venous insufficiency that develop following Deep vein thrombosis
- Consequence of long-standing venous hypertension thought to be due to a combination of thrombotic vein occlusion and venous valvular incompetence.
- Post-thrombotic syndrome occurs in up to 50 percent of patients within the first year following acute thrοmbоsiѕ, despite anticoagulation.
- Severe post-thrombotic syndrome develops in 5 to 10 percent of patients.
- Risks
- Prior primary venous insufficiency
- Older age
- Obesity
- Preexisting varicose veins.
- Proximal DVТ
- Inadequate anticoagulation during initial treatment of DVТ
- Residual thrombus in the vein
- Recurrent DVТ
- Clinical features
- Chronic venous insufficiency
- Extremity pain, limb heaviness, vein dilation, extremity eԁеma, skin pigmentation, trophic skin changes, and venous ulcers.
- Eԁеmа is the most common manifestation
- Diagnosis
- Clinical
- Venous imaging, typically duplex ultrasound, may be useful for patients in whom the clinical signs of chronic venous insufficiency are not obvious, those with a clinical history that suggests DVТ but in whom studies were not performed, or to identify proximal vein stenosis or occlusion in those with severe symptoms.
- Management
- Like that for other patients with chronic venous disease
- Venous intervention
- Severe symptoms and evidence of proximal vein stenosis or occlusion on vein imaging studies, venous intervention may decrease the incidence of skin changes and ulceration and improve quality of life.