Definition
Sclerosing adenosis is a lobular lesion with increased fibrous tissue and interspersed glandular cells. It can present as a mass or a suspicious finding on mammography. The risk of subsequent breast cancer in those with sclerosing adenosis is about twofold that in the general population. Currently, no treatment, chemoprevention, or enhanced screening is recommended for sclerosing adenosis in the absence of atypia.
- Sclerosing adenosis
- Proliferation of terminal duct lobules (enlargement & distortion)
- ↑ no. of acini + fibrous stromal ∆ with intralobular fibrosis
- ± Associated with microcalcifications
- Differentiated from Radial Scars (RS)/ Complex Sclerosing Lesion (CSL) by degree of excessive myoepithelial proliferation seen in RS and CSL
Management
- Presence of sclerosing adenosis alone in a core biopsy does not require surgical excision