Taxane

• The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and taxanes stabilize GDP-bound tubulin in the microtubule, thereby inhibiting the process of cell division as depolymerization is prevented.

• Paclitaxel

  • CROSS Trial - treatment of Oesophageal cancer
  • Early-stage breast cancer

• Docetaxel

  • FLOT4 - treatment of Gastric adenocarcinoma

Chemotherapy

• Anti-microtubule agents - antineoplastic drugs that inhibit mitosis by interfering with microtubule formation during cell division

Side Effects

• Taxane (Paclitaxel)
  • Neuropathy